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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
12.42
Human Site:
T414
Identified Species:
21.03
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
T414
K
P
Q
P
R
P
Q
T
L
R
K
S
N
S
F
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
T414
K
P
Q
P
R
P
Q
T
L
R
K
S
N
S
F
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
T414
K
P
Q
P
K
P
Q
T
L
R
K
S
S
S
F
Dog
Lupus familis
XP_534917
565
65190
Y458
P
R
N
L
K
P
R
Y
R
P
Q
T
L
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
P525
P
R
K
F
K
P
R
P
K
P
Q
I
L
R
K
Rat
Rattus norvegicus
Q4V8A3
586
65492
R470
L
L
G
G
R
S
R
R
G
K
K
R
G
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
F361
S
S
R
K
Q
T
F
F
D
S
E
G
F
P
K
Chicken
Gallus gallus
Q5ZIU3
526
59419
R419
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
Frog
Xenopus laevis
Q2TAE3
750
84138
Q552
H
S
P
Q
V
R
Q
Q
F
P
P
G
W
T
V
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
P522
R
L
H
P
K
P
R
P
L
R
K
E
S
D
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
S508
R
H
R
S
C
R
M
S
S
S
S
S
S
S
G
Honey Bee
Apis mellifera
XP_396369
614
68978
I490
V
S
S
S
T
S
T
I
A
A
S
T
V
N
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
H295
G
E
A
L
F
Q
T
H
D
N
L
E
H
L
A
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
H679
Q
N
R
E
C
L
I
H
F
L
G
G
V
L
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
86.6
6.6
N.A.
6.6
13.3
N.A.
0
6.6
6.6
33.3
N.A.
13.3
0
N.A.
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
33.3
26.6
N.A.
20
13.3
13.3
60
N.A.
40
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
8
8
0
0
8
0
15
% A
% Cys:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
15
0
0
0
0
8
0
% D
% Glu:
0
8
0
8
0
8
0
0
8
0
8
15
0
0
0
% E
% Phe:
0
0
0
8
8
0
8
8
15
0
0
0
8
0
22
% F
% Gly:
8
0
15
8
0
0
0
0
8
0
15
22
8
0
8
% G
% His:
8
8
8
0
0
0
0
15
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
8
8
0
0
0
8
0
0
0
% I
% Lys:
22
0
8
8
29
0
0
0
8
8
36
0
0
0
29
% K
% Leu:
15
15
0
15
0
8
0
0
29
8
8
0
15
22
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
0
0
0
0
8
0
8
15
8
15
% N
% Pro:
15
22
8
36
8
43
0
15
0
22
8
0
0
15
8
% P
% Gln:
8
0
22
8
8
8
29
8
0
0
15
0
0
0
0
% Q
% Arg:
15
22
22
0
22
15
29
15
8
29
0
8
0
15
0
% R
% Ser:
8
22
8
15
0
15
8
8
8
15
15
29
22
29
0
% S
% Thr:
0
0
0
0
8
8
15
22
0
0
0
15
0
8
0
% T
% Val:
8
0
0
0
8
0
0
0
0
0
0
0
15
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _